Bui National Park is the third largest Wildlife Protected Area in the country. It covers 1,821km² and is bisected by the Black Volta. It is located in a typical woodland savanna zone in the Brong Ahafo and Northern Region of Ghana. It has spectacular gallery forests along rivers courses.

The reserve is particularly notable for its resident Hippo population in the Black Volta. Primates like the endangered black and white colobus monkey and a variety of antelopes and birds are also present.